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Vitrification is revolutionising egg donation for fertility treatment.

Vitrification is revolutionising egg donation for fertility treatment.




Vitrification will be able to provide freeze-storage egg-banking instead of relying on donors to be present during a ‘fresh’ treatment cycle for egg collection. This allows a majority of the patients to have immediate fertility treatments since there is a variety of donors that can be matched without having to wait for a fresh-donor match.


Evidence from several commercial frozen egg banks supports the process of vitrification for egg banking.

Dr. Ana Cobo from Valencia Infertility Institute in Spain presented research at the Annual Meeting of ESHRE in Munich (2014) which demonstrated the number of vitrified eggs patient require to maximize pregnancy.

This study was undertaken and the findings signal how many frozen eggs an IVF patient may require to increase the chance of pregnancy and future delivery (live birth rate). These results summarized by Science Daily (July 1, 2014) are quoted below:


(1)  The study analysed the experience of more than 3400 patients using an egg bank for egg donation treatment (and more than 40,000 vitrified oocytes) and found that cumulative live birth rates (CLBR) were high and increased progressively according to the number of eggs used in the treatments, and then reached a plateau.


(2)  CLBR was found to be 39.4% when a total of ten vitrified eggs were used in the treatments, and 75.9% when a total of 20 eggs were used. But this rapid rate of increase slowed when 30 eggs were used, to 88.7%, and thereafter reached a peak with the use of 40 vitrified eggs at 97.3%.


(3)  The probability of having a baby increases progressively according to the number of oocytes consumed. This increase is rapid until oocyte numbers reach 10-12, and slower from the 20th onwards, reaching a plateau close to 100% when 40 vitrified oocytes have been used.


Dr. Cobo notes that “there is the possibility of having a greater availability of stored oocytes from donor tested for a genetic condition or rare blood type, and, most importantly, the donation would be safer because of the quarantine period.”

Information obtained from the trials is also useful for those younger women who have chosen oocyte vitrification as an option for fertility preservation.

Dr. Cobo and colleagues have also demonstrated that pregnancy rates are comparable between fresh IVF and eggs warmed after vitrification. Currently they report a pregnancy rate (per oocytes warming, 2013) of 64%.